Journal Club october 2021

In the part with the review articles you can read interesting (but sometimes short) contributions on breastfeeding in Down syndrome, ethical concerns regarding vaccination in children, sudden infant death syndrome, facemasks and smiles…


In the part with the clinical studies you may find the answer to the following questions:


  • What is the best way to decrease CPAP failure in preterm infants?
  • Is there a reliable calculator to predict early onset sepsis in neonates?
  • Is prenatal antibiotic exposure associated with ALL in children? Or could it impair neurodevelopment?
  • Does folic acid supplementation lead to fewer congenital heart defects?
  • Do we see fewer congenital CMV infections due to the pandemic?
  • Does ADHD medication have an impact on weight and height, or just on weight?
  • Can more screen time lead to more emotional problems?
  • Did the coronavirus pandemic lead to a form of atypical anorexia nervosa?
  • What are risk factors for AKI after cardiac surgery?
  • What type of medication is most often used in paediatric palliative patients?
  • Is it useful to do pre-emptive interventions when suspecting autism?
  • How long do children need to sit to develop back pain?
  • Should we reduce screen time after a concussion?


Selection of articles for the Pediatric Journal Club: october 2021




Can I breastfeed my baby with Down syndrome? A scoping review.

Zhen L, et al. J Paediatr Child Health. 2021 Sep 29.


Clinical ethics: consent for vaccination in children.

Wilkinson D, et al. Arch Dis Child. 2021 Sep 27:archdischild-2021-322981.


Assessment, diagnosis, and management of developmental coordination disorder.

Ip A, et al. Paediatr Child Health. 2021 Sep 17;26(6):375-378.


Half Century Since SIDS: A Reappraisal of Terminology.

Shapiro-Mendoza CK, et al. Pediatrics. 2021 Oct;148(4):e2021053746.


Facemasks during COVID-19 and the importance of smiles in developmental assessment.

Snow L. Arch Dis Child. 2021 Sep 3:archdischild-2021-322659.




Late Pre-term Infants With Severe Bronchiolitis and Risk of Asthma by Age 5 Years.

Mansbach JM, et al. J Pediatr. 2021 Sep 29:S0022-3476(21)00913-6.


Antenatal corticosteroids and neurodevelopmental outcomes in late preterm births.

Aviram A, et al. Arch Dis Child Fetal Neonatal Ed. 2021 Sep 29


Decreasing Continuous Positive Airway Pressure Failure in Preterm Infants.

Kakkilaya VB, et al. Pediatrics. 2021 Oct;148(4):e2020014191.


Neonatal Early Onset Sepsis: Impact of Kaiser Calculator in an Italian Tertiary Perinatal Center.

Pontello E, et al. Pediatr Infect Dis J. 2021 Sep 9.


Machine Learning Used to Compare the Diagnostic Accuracy of Risk Factors, Clinical Signs and Biomarkers and to Develop a New Prediction Model for Neonatal Early-onset Sepsis.

Stocker M, et al. Pediatr Infect Dis J. 2021 Sep 9.


Maternal antibiotics exposure during pregnancy and the risk of acute lymphoblastic leukemia in childhood: a systematic review and meta-analysis.

Zhu X, et al. Eur J Pediatr. 2021 Sep 17.


Maternal Periconceptional Folic Acid Supplementation and Risk for Fetal Congenital Heart Defects.

Wang D, et al. J Pediatr. 2021 Sep 8:S0022-3476(21)00876-3.


Child growth and neurodevelopment after maternal antenatal antibiotic treatment.

Videman K, et al. Arch Dis Child. 2021 Sep 3:archdischild-2021-322043.


Perinatal outcomes among births to women with infection during pregnancy.

Baguiya A, et al. Arch Dis Child. 2021 Oct;106(10):946-953.


Lower prevalence of congenital cytomegalovirus infection in Portugal: possible impact of COVID-19 lockdown?

Fernandez C, et al. Eur J Pediatr. 2021 Sep 30:1-4.


The Role of Antenatal and Postnatal Maternal Bonding in Infant Development.

Le Bas G, et al. J Am Acad Child Adolesc Psychiatry. 2021 Sep 17:S0890-8567(21)01810-4.


Postoperative Rather Than Preoperative Neutropenia Is Associated With Early Catheter-related Bloodstream Infections in Newly Diagnosed Pediatric Cancer Patients.

Cher WQ, et al. Pediatr Infect Dis J. 2021 Sep 28.


Psychosocial functioning in adolescents growing up with chronic disease: The Dutch HBSC study.

Berkelbach van der Sprenkel EE, et al. Eur J Pediatr. 2021 Sep 30.


Elevated liver enzymes of newly diagnosed pediatric celiac patients-a prospective-observational study.

Regev A, et al. Eur J Pediatr. 2021 Sep 29.


Prevalence of neurological problems in a community-based sample of paediatric coeliac disease: a cross-sectional study.

O’Neill T, et al. Arch Dis Child. 2021 Sep 28:archdischild-2021-321770.


Predictors of Changes in Height, Weight, and Body Mass Index after Initiation of Central Nervous System Stimulants in Children with Attention-Deficit/Hyperactivity Disorder.

Waxmonsky JG, et al. J Pediatr. 2021 Sep 24:S0022-3476(21)00906-9.


Dynamics of RT-PCR and Serologic Test Results in Children with SARS-CoV-2 Infection.

Tagarro A, et al. J Pediatr. 2021 Sep 24:S0022-3476(21)00905-7.


Association Between Leisure Screen Time and Emotional and Behavioural Problems in Spanish Children.

Cartanyà-Hueso À, et al. J Pediatr. 2021 Sep 24:S0022-3476(21)00907-0.


Impact of the coronavirus pandemic on anorexia nervosa and atypical anorexia nervosa presentations to an Australian tertiary paediatric hospital.

Springall G, et al. J Paediatr Child Health. 2021 Sep 27.


Risk factors for acute kidney injury after pediatric cardiac surgery: a meta-analysis.

Van den Eynde J, et al. Pediatr Nephrol. 2021 Sep 30.


Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial.

NICUSeq Study Group. JAMA Pediatr. 2021 Sep 27.


Nature and Children’s Health: A Systematic Review.

Fyfe-Johnson AL, et al. Pediatrics. 2021 Oct;148(4):e2020049155.


Increasing rate of a positive family history of inflammatory bowel disease (IBD) in pediatric IBD patients.

Ruban M, et al. Eur J Pediatr. 2021 Sep 26.


Obstructive sleep apnea in children with Down syndrome: is it possible to predict severe apnea?

Hizal M, et al. Eur J Pediatr. 2021 Sep 25:1-9.


Burnout and Perceptions of Stigma and Help-Seeking Behavior Among Pediatric Fellows.

Weiss AK, et al. Pediatrics. 2021 Oct;148(4):e2021050393.


Medication chart review at end of life of paediatric palliative patients.

Soo JEJ, et al. J Paediatr Child Health. 2021 Sep 23.


A Text-Based Intervention to Promote Literacy: An RCT.

Chamberlain LJ, et al. Pediatrics. 2021 Oct;148(4):e2020049648.


Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis.

Whitehouse AJO, et al. JAMA Pediatr. 2021 Sep 20:e213298.


The Presentation of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Influenced by the Presence or Absence of Joint Hypermobility.

Vogel SK, et al. J Pediatr. 2021 Sep 16:S0022-3476(21)00887-8.


Healthcare Experiences Of Gender Diverse Youth Across Clinical Settings.

Sequeira GM, et al. J Pediatr. 2021 Sep 15:S0022-3476(21)00888-X.


Assessing the optimal time interval between growth measurements using a combined data set of weights and heights from 5948 infants.

Wright CM, et al. Arch Dis Child. 2021 Sep 14:archdischild-2021-322479.


How Much Does Serum 25(OH)D Improve by Vitamin D Supplement and Fortified Food in Children? A Systematic Review and Meta-Analysis.

Nikooyeh B, et al. J Pediatr Gastroenterol Nutr. 2021 Sep 13.


Depression in Adolescent Females With Heavy Menstrual Bleeding.

Weyand AC, et al. J Pediatr. 2021 Sep 10:S0022-3476(21)00880-5.


Exceeding 2-h sedentary time per day is not associated with moderate to severe spinal pain in 11- to 13-year-olds: a cross-sectional analysis.

Montgomery LRC, et al. Eur J Pediatr. 2021 Sep 12.


Trajectories of Suicidal Thoughts and Behaviors From Preschool Through Late Adolescence.

Whalen DJ, et al. J Am Acad Child Adolesc Psychiatry. 2021 Sep


Making a diagnosis of periodic fever syndrome: Experience from a single tertiary centre.

McNaughton P, et al. J Paediatr Child Health. 2021 Sep 9.


Development of an integrated competency framework for postgraduate paediatric training: a Delphi study.

Robbrecht M, et al. Eur J Pediatr. 2021 Sep 8:1-10.


High-Intensity Interval Training and Cardiometabolic Risk Factors in Children: A Meta-analysis.

Solera-Martínez M, et al. Pediatrics. 2021 Oct;148(4):e2021050810.


Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial.

Macnow T, et al. JAMA Pediatr. 2021 Sep 7:e212782.


A Definitive Answer to the Effect of Screen Time on Concussion Recovery.

Chrisman SPD. JAMA Pediatr. 2021 Sep 7.


Timing of Introduction to Solid Food, Growth, and Nutrition Risk in Later Childhood.

D’Hollander CJ, et al. J Pediatr. 2021 Sep 2:S0022-3476(21)00861-1.


Off-label drug use in paediatric haemato-oncology patients: financial implications and proposed solutions for Belgian patients.

Bauters T, et al. Eur J Pediatr. 2021 Sep;180(9):3067-3071.


Household Transmission of SARS-CoV-2 from Children and Adolescents.

Chu VT, et al. N Engl J Med. 2021 Sep 2;385(10):954-956.




Is the NICE traffic light system fit-for-purpose for children presenting with undifferentiated acute illness in primary care?

Blyth MH, et al. Arch Dis Child. 2021 Sep 21:archdischild-2021-322768.


A Tool to Distinguish Viral From Bacterial Pneumonia.

Tagarro A, et al. Pediatr Infect Dis J. 2021 Sep 14.


Viewpoint of the European Pediatric Societies over Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in Children Younger Than Age 12 Years Amid Return to School and the Surging Virus Variants.

Pettoello-Mantovani M, et al. J Pediatr. 2021 Sep 15:S0022-3476(21)00886-6.


Validating clinical practice guidelines for the management of febrile infants presenting to the emergency department in the UK and Ireland.

Waterfield T, et al. Arch Dis Child. 2021 Sep 16:archdischild-2021-322586.




Severe Cyanosis in a Toddler.

Dalby ST, et al. J Pediatr. 2021 Sep 28:S0022-3476(21)00912-4.


From testis to brucellosis: A report of two paediatric cases presenting with acute scrotum.

Bako D, et al. J Paediatr Child Health. 2021 Sep 30.


The limping child’s curvy diagnosis.

Wong NX, et al. J Paediatr Child Health. 2021 Sep 30.


Recipe for Disaster: Homemade Formula Leading to Severe Complications in 2 Infants.

Vieira MA, et al. Pediatrics. 2021 Sep;148(3):e2021050947.


Case 27-2021: A 16-Year-Old Boy Seeking Human Immunodeficiency Virus Prophylaxis.


Neilan AM, et al. N Engl J Med. 2021 Sep 9;385(11):1034-1041.