Journal Club april 2020

I have added a section on Covid-19 as it is important to keep up-to-date with the published literature. I have not included all articles that have been published, but have ‘restricted’ the selection to the pediatric population.


In the part with the review articles, you can read interesting manuscripts on: abusive head trauma, obesity treatment, neonatal sepsis and NEC, timeline on radiologic healing of fractures, PID…


In the part with the original studies you may find the answer to the following questions:

  • What are the maturational changes of the esophagus in preterm infants?
  • What is pentoxifyllin and why would neonatologists start to use it?
  • Do we need to fear NEC in infants with congenital heart disease?
  • Can melatonin be used as sedative in newborns and can it be used post-concussion?
  • Do children with a solitary kidney have a higher risk of hypertension?
  • Is it useful to have a parental questionnaire to detect seizures in high-risk children?
  • Does migraine change during puberty?
  • Does a lack of fibre cause childhood constipation?
  • Is pyelonephritis possible in children who display neither pyuria nor bacteriuria?
  • Is a short-course of antibiotics useful for chemotherapy-induced febrile neutropaenia?
  • Are proton pump inhibitors associated with an increased risk of fractures?
  • Is there too much neonatal testing in infants with maternal thyroid disease?
  • Are maternal autoimmune disorders associated with Kawasaki disease in young children?


Selection of articles for the Pediatric Journal Club: APRIL 2020




Vertical Transmission of Coronavirus Disease 19 (COVID-19) from Infected Pregnant Mothers to Neonates: A Review. Karimi-Zarchi M, et al. Fet Ped Path. 2020 Apr 2:1-5 (39 cases, no transmission)


Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children. Hong H, et al. Pediatr Neonatol. 2020 Mar 10. (9 newborn cases > no/mild disease)


Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records.

Chen H, et al. Lancet. 2020 Mar 7;395(10226):809-815.  (9 cases > no vertical transmission)


Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. Zeng L, et al. JAMA Pediatr. 2020 Mar 26. (33 neonates > 3 symptomatic, mild disease)


Proposal for prevention and control of the 2019 novel coronavirus disease in newborn infants.

Li F, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Mar 4 (letter to the editor > very short guideline)


Novel 2019 coronavirus SARS-CoV-2 (COVID-19): An updated overview for emergency clinicians

Giwa AL, et al. Emerg Med Pract. 2020 May 1;22(5):1-28


COVID-19 in Children: Initial Characterization of the Pediatric Disease.

Pediatrics. 2020 Mar 16.


COVID-19 epidemic: disease characteristics in children.

Jiatong S, et al. J Med Virol. 2020 Mar 31.


COVID-19 infection in children.

Sinha IP, et al. Lancet Respir Med. 2020 Mar 27.


Why is COVID-19 so mild in children?

Brodin P. Acta Paediatr. 2020 Mar 25


Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission.

Tian Y, et al. Aliment Pharmacol Ther. 2020 Mar 29.


Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Qiu H, et al. Lancet Infect Dis. 2020 Mar 25


Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults.

Ludvigsson JF. Acta Paediatr. 2020 Mar 23


Chest computed tomography in children with COVID-19 respiratory infection.

Li W, et al. Pediatr Radiol. 2020 Mar 11.


High-Resolution Computed Tomography Manifestations of 5 Pediatric Patients With 2019 Novel Coronavirus. Liu M, et al. J Comput Assist Tomogr. 2020 Mar 25.


Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China.

Dong Y, et al. Pediatrics. 2020 Mar 16


Mitigate the effects of home confinement on children during the COVID-19 outbreak.

Wang G, et al. Lancet. 2020 Mar 21;395(10228):945-947.


What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families?

Thompson LA, et al. JAMA Pediatr. 2020 Mar 13.


Parenting in a time of COVID-19.

Cluver L, et al. Lancet. 2020 Mar 25




Abusive Head Trauma in Infants and Children.

Narang SK, et al. Pediatrics. 2020 Apr;145(4). pii: e20200203.


Obesity Treatment Among Adolescents: A Review of Current Evidence and Future Directions.

Cardel MI, et al. JAMA Pediatr. 2020 Mar 23.


Neonatal sepsis: need for consensus definition, collaboration and core outcomes.

Molloy EJ, et al. Pediatr Res. 2020 Mar 19.


Radiographic timelines for pediatric healing fractures: a systematic review.

Messer DL, et al. Pediatr Radiol. 2020 Mar 10.


Necrotizing Enterocolitis: The Future.

Neu J. Neonatology. 2020 Mar 10:1-5.


Functional abdominal pain: what clinicians need to know.

Andrews ET, et al. Arch Dis Child. 2020 Mar 9.


Primary immunodeficiencies and their associated risk of malignancies in children: an overview.

Renzi S, et al. Eur J Pediatr. 2020 Mar 11.




Maturation of Esophageal Motility and Esophagogastric Junction in Preterm Infants.

Rayyan M, et al. Neonatology. 2020 Mar 24:1-9.


Trends in incidence and outcomes of necrotizing enterocolitis over the last 12 years: A multicenter cohort analysis. Han SM, et al. J Pediatr Surg. 2020 Feb 29.


Intravenous pentoxifylline is well tolerated in critically ill preterm infants with sepsis or necrotizing enterocolitis. Schüller SS, et al. Eur J Pediatr. 2020 Mar 16


“How can a drug to treat claudication in adults save preterm newborns?”

Kurul S, et al. Eur J Pediatr. 2020 Mar 16


Low risk of necrotising enterocolitis in enterally fed neonates with critical heart disease: an observational study. Nordenström K, et al. Arch Dis Child Fetal Neonatal Ed. 2020 Mar 13.


Culture-proven Bloodstream Infections at a Specialist Pediatric Hospital.

Al Yazidi LS, et al. Pediatr Infect Dis J. 2020 Mar 20


Efficacy of Melatonin in Children With Postconcussive Symptoms: A Randomized Clinical Trial.

Barlow KM, et al. Pediatrics. 2020 Apr;145(4).


Melatonin is useful alternative for sedation in children undergoing auditory brainstem responses testing. Hajjij A, et al. Eur J Pediatr. 2020 Mar 16


Born with a solitary kidney: at risk of hypertension.

La Scola C, et al. Pediatr Nephrol. 2020 Mar 24.


Dietary Fats and Atherosclerosis From Childhood to Adulthood.

Laitinen TT, et al. Pediatrics. 2020 Apr;145(4).


Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood.

Juonala M, et al. Pediatrics. 2020 Apr;145(4).


Paediatric empyema: worsening disease severity and challenges identifying patients at increased risk of repeat intervention. Haggie S, et al. Arch Dis Child. 2020 Mar 24


Clinical Implementation of a Parent Questionnaire to Identify Seizures in High-Risk Children.

Greenlaw C, et al. J Child Neurol. 2020 Mar 24:883073820911505.


Manifestation of migraine in adolescents: Does it change in puberty?

Böttcher B, et al. Eur J Paediatr Neurol. 2020 Feb 20


Challenging the view that lack of fibre causes childhood constipation.

Tappin D, et al. Arch Dis Child. 2020 Mar 10.


Excessive screen time is associated with maternal rejection behaviours in pre-school children.

Erat Nergiz M, et al. J Paediatr Child Health. 2020 Mar 20.


Clinical Characteristics of Pediatric Pyelonephritis Without Pyuria or Bacteriuria.

Yokoyama T, et al. Pediatr Infect Dis J. 2020 Mar 13.


Short-course antibiotics for chemotherapy-induced febrile neutropaenia: retrospective cohort study.

Seneviratne N, et al.. Arch Dis Child. 2020 Mar 17.


Antibiotic Use and Outcomes in Children in the Emergency Department With Suspected Pneumonia.

Lipshaw MJ, et al. Pediatrics. 2020 Apr;145(4).


Antibiotic Prescribing for Viral Respiratory Infections in the Pediatric Emergency Department and Urgent Care. Desai NM, et al. Pediatr Infect Dis J. 2020 Mar 5.


Association Between Proton Pump Inhibitor Use and Risk of Fracture in Children.

Wang YH, et al. JAMA Pediatr. 2020 Mar 16.


Acute Cerebellitis or Postinfectious Cerebellar Ataxia? Clinical and Imaging Features in Acute Cerebellitis. Yildirim M, et al. J Child Neurol. 2020 Mar 12:883073820901407


Unique Features of Hospitalized Children with Alveolar Pneumonia Suggest Frequent Viral-Bacterial Coinfections. Gavrieli H, et al. Pediatr Infect Dis J. 2020 Mar 5.


Reducing unnecessary neonatal testing in infants of mothers with thyroid disease.

Churcher LM, et al. J Paediatr Child Health. 2020 Mar 16


Longitudinal neurodevelopmental outcomes in preterm twins.

Christensen R, et al. Pediatr Res. 2020 Mar 14.


Maternal Autoimmune Disorders and Risk of Kawasaki Disease in Offspring.

Belkaibech S, et al. J Pediatr. 2020 Mar 11


Acute kidney injury in critically ill children and 5-year hypertension.

Hessey E, et al. Pediatr Nephrol. 2020 Mar 11.


The Infantile Hemangioma Referral Score: A Validated Tool for Physicians.

Léauté-Labrèze C, et al. Pediatrics. 2020 Apr;145(4).


Efficacy and Effectiveness of the PCV-10 and PCV-13 Vaccines Against Invasive Pneumococcal Disease. Berman-Rosa M, et al. Pediatrics. 2020 Apr;145(4).


Infant sleep and child mental health: a longitudinal investigation.

Cook F, et al. Arch Dis Child. 2020 Mar 9.


Maternal age at delivery and fertility of the next generation.

Reynolds TS, et al. Paediatr Perinat Epidemiol. 2020 Mar 9.


Association Between Rotavirus Vaccination and Type 1 Diabetes in Children.

Glanz JM, et al. JAMA Pediatr. 2020 Mar 9


A Longitudinal Investigation of Symptom Recovery following Concussion in Youth Soccer.

Kirkwood MW, et al. J Pediatr. 2020 Mar 5.


Assessment of anti-infective medication adherence in pediatric outpatients.

Warembourg M, et al. Eur J Pediatr. 2020 Mar 5.


Mycoplasma pneumoniae in Children With and Without Community-acquired Pneumonia. What do PCR and Serology Say? Copete AR, et al. Pediatr Infect Dis J. 2020 Feb 28.


Consequences of Undervaccination – Measles Outbreak, New York City, 2018-2019.

Zucker JR, et al. N Engl J Med. 2020 Mar 12;382(11):1009-1017




Prevention of Childhood Obesity. A Position Paper of the global Federation of International Societies of International Societies of Pediatric Gastroenterology, Hepatology and Nutrition (FISPGHAN).

Koletzko B, et al. J Pediatr Gastroenterol Nutr. 2020 Mar 20




Sudden visual loss: A not so simplex case.

Sampson MCR, et al. J Paediatr Child Health. 2020 Mar;56(3):484


Weakness, Anemia, and Neutropenia in a 9-Year-Old Girl With Influenza.

Cohen A, et al. Pediatrics. 2020 Apr;145(4