Journal Club november 2019

In the part with the review articles there are interesting contributions on: rickets, bilirubin neurotoxicity, Kawasaki disease, the promise of an EBV vaccine, Tourette’s syndrome, soccer injuries…


In the part with the clinical studies you may find the answer to the following questions:


  • Is lung ultrasound a useful investigation in preterms with RDS?
  • Which biomarkers can predict intestinal recovery after NEC?
  • Which nutritional interventions can reduce NEC?
  • Can acoustic analysis identify pain in infants?
  • What factors are associated with fast recovery after Bell’s palsy?
  • Is exome sequencing useful in the workup of developmental delay and syndromic short stature?
  • Which pain and sedation scales are the best in preverbal children?
  • What can we learn from a trial on endotracheal suctioning for the prevention of meconium aspiration?
  • Is bronchiolitis severity associated with recurrent wheeze at age 3?
  • Which mental health conditions are associated with hyperthyroidism?
  • Does head circumference at birth correlate with intellectual disability?
  • Is chocolate consumption good for your telomeres?
  • What are the long-term effects of statins in children with hypercholesterolaemia?
  • Is it better to increase milk feeding volume in preterms fast or slow?


Selection for the Pediatric Journal Club: NOVEMBER 2019.




A brief history of rickets.

Friedman A. Pediatr Nephrol. 2019 Oct 25.


Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.

Riordan SM, et al. Pediatr Res. 2019 Oct 10.


Review of bilirubin neurotoxicity II: preventing and treating acute bilirubin encephalopathy and kernicterus spectrum disorders.

Shapiro SM, et al. Pediatr Res. 2019 Oct 3.


Kawasaki disease: origins and evolution.

Kainth R, et al. Arch Dis Child. 2019 Oct 18.


The Spartacus Problem: Diagnostic Inefficiency of Neonatal Sepsis.

Cantey JB. Pediatrics. 2019 Nov;144(5).


The promise of a prophylactic Epstein-Barr virus vaccine.

Balfour HH Jr, et al. Pediatr Res. 2019 Oct 3.


Imaging surveillance for children with predisposition to renal tumors.

Srinivasan AS, et al. Pediatr Radiol. 2019 Oct;49(11):1453-1462.


Clinical Features of Tourette Syndrome.

Gill CE, Kompoliti K. J Child Neurol. 2019 Oct 14:883073819877335.


Seeking a Second Opinion on Social Media.

Caruso Brown AE, et al. Pediatrics. 2019 Nov;144(5).


Early childhood caries epidemiology, aetiology, risk assessment, societal burden, management, education, and policy: Global perspective.

Tinanoff N, et al. Int J Paediatr Dent. 2019 May;29(3):238-248.


Soccer Injuries in Children and Adolescents.

Watson A, et al. Pediatrics. 2019 Nov;144(5).




Flavored E-cigarette Use and Progression of Vaping in Adolescents.

Leventhal AM, et al. Pediatrics. 2019 Nov;144(5).


Use of Intraosseous Needles in Neonates: A Systematic Review.

Scrivens A, , et al. Neonatology. 2019 Oct 28:1-10.


Lung ultrasound in preterm infants with respiratory distress: experience in a neonatal intensive care unit.

Gregorio-Hernández R, et al. Eur J Pediatr. 2019 Oct 26.


Use of clinician-performed ultrasound in the assessment of safe umbilical venous catheter tip placement.

Seigel A, et al. J Paediatr Child Health. 2019 Oct 26.


Strengthening Diagnosis of Pulmonary Tuberculosis in Children: The Role of Xpert MTB/RIF Ultra.

Zar HJ, et al. Pediatrics. 2019 Nov;144(5).


A Test for More Accurate Diagnosis of Pulmonary Tuberculosis.

Sun L, et al. Pediatrics. 2019 Nov;144(5).


Accelerating diagnosis for childhood brain tumours: an analysis of the HeadSmart UK population data.

Shanmugavadivel D, et al. Arch Dis Child. 2019 Oct 25.


Predicting intestinal recovery after necrotizing enterocolitis in preterm infants.

Kuik SJ, et al. Pediatr Res. 2019 Oct 24.


Nutritional interventions to reduce rates of infection, necrotizing enterocolitis and mortality in very preterm infants.

Bührer C, et al. Pediatr Res. 2019 Oct 23.


Newborn Antibiotic Exposures and Association With Proven Bloodstream Infection.

Schulman J, et al. Pediatrics. 2019 Nov;144(5).


Defining and distinguishing infant behavioral states using acoustic cry analysis: is colic painful?

Parga JJ, et al. Pediatr Res. 2019 Oct 4.


Prevalence and Factors Associated With Safe Infant Sleep Practices.

Hirai AH, et al. Pediatrics. 2019 Nov;144(5).


Duration of initial antibiotic course is associated with recurrent relapse in protracted bacterial bronchitis.

Gross-Hodge E, et al. Arch Dis Child. 2019 Oct 17.


Factors Associated With Fast Recovery of Bell Palsy in Children.

Lee Y, et al. J Child Neurol. 2019 Oct 17:883073819877098


Mapping 123 million neonatal, infant and child deaths between 2000 and 2017.

Burstein R, et al. Nature. 2019 Oct;574(7778):353-358.


Diagnostic and Clinical Utility of Clinical Exome Sequencing in Children With Moderate and Severe Global Developmental Delay / Intellectual Disability.

Stojanovic JR, et al. J Child Neurol. 2019 Oct 17:883073819879835.


Genetic Disorders in Prenatal Onset Syndromic Short Stature Identified by Exome Sequencing.

Homma TK, et al. J Pediatr. 2019 Oct 17.


Predictors and Outcomes of Early Intubation in Infants Born at 28-36 Weeks of Gestation Receiving Noninvasive Respiratory Support.

Roberts CT, et al. J Pediatr. 2019 Oct 11


Pain and Sedation Scales for Neonatal and Pediatric Patients in a Preverbal Stage of Development: A Systematic Review.

Giordano V, et al. JAMA Pediatr. 2019 Oct 14.


Effect of Exercise Recommendation on Adolescents With Concussion.

Stumph J, et al. J Child Neurol. 2019 Oct 10:883073819877790.


Endotracheal suctioning for prevention of meconium aspiration syndrome: a randomized controlled trial.

Kumar A, et al. Eur J Pediatr. 2019 Oct 7.


Bronchiolitis severity is related to recurrent wheezing by age 3 years in a prospective, multicenter cohort.

Mansbach JM, et al. Pediatr Res. 2019 Oct 4.


Mental Health Conditions and Hyperthyroidism.

Zader SJ, et al. Pediatrics. 2019 Nov;144(5).


Head circumference at birth and intellectual disability: a nationwide cohort study.

Aagaard K, et al. Pediatr Res. 2019 Oct 2.


Unintentional Symptom Intensification by Doctors.

Schechter NL, et al. Pediatrics. 2019 Nov;144(5).


Higher chocolate intake is associated with longer telomere length among adolescents.

Chen L, et al. Pediatr Res. 2019 Oct 1.


20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia.

Luirink IK, et al. N Engl J Med. 2019 Oct 17;381(16):1547-1556.


Controlled Trial of Two Incremental Milk-Feeding Rates in Preterm Infants.

Dorling J, et al. N Engl J Med. 2019 Oct 10;381(15):1434-1443.




The Use of Nonnutritive Sweeteners in Children.

Baker-Smith CM, et al. Pediatrics. 2019 Nov;144(5).


What clinical practice strategies have been shown to decrease incidence rates of intraventricular haemorrhage in preterm infants?

Howes A, et al. J Paediatr Child Health. 2019 Oct;55(10):1269-1278.


Concussion Management for Children Has Changed: New Pediatric Protocols Using the Latest Evidence.

DeMatteo C, et al. Clin Pediatr (Phila). 2019 Oct 18:9922819879457.


Post-traumatic Headache After Pediatric Traumatic Brain Injury: Prevalence, Risk Factors, and Association With Neurocognitive Outcomes.

McConnell B, et al. J Child Neurol. 2019 Oct 4:883073819876473.


Postnatally acquired cytomegalovirus infection in extremely premature infants: how best to manage?

Kadambari S, et al. Arch Dis Child Fetal Neonatal Ed. 2019 Oct 15.


Diagnostic values of the femoral pulse palpation test.

Khammari Nystrom F, et al. Arch Dis Child Fetal Neonatal Ed. 2019 Oct 9.


Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.

Wolraich ML, et al. Pediatrics. 2019 Oct;144(4).


Canadian Paediatric Society clinical practice recommendations for assessment of children and youth with autism spectrum disorder.

Zwaigenbaum L, et al.  Paediatr Child Health. 2019 Nov;24(7):421-423.


Acute Treatment of Migraine in Children and Adolescents.

Pediatrics. 2019 Nov;144(5).  (AAP endorsement of: and




12-Year-old Female with Mucocutaneous Lesions.

Marujo F, et al. Pediatr Infect Dis J. 2019 Nov;38(11):1159.


Three-year-old girl with progressive leg pain, weakness and refusal to ambulate.

Gallagher J, et al. J Paediatr Child Health. 2019 Oct 17.


A 15-Year-Old Girl with a Squint.

Tan GH. J Pediatr. 2019 Oct 11.


The Case of a Twitchy Tongue: An Uncommon Presentation of a Common Childhood Epilepsy.

Khalid R, et al.  J Pediatr. 2019 Oct 9.